2026-04-17T12:02:51Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/584412025-12-20T16:50:12Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Alegre Zurano, Laia author Cáceres-Rodriguez, Alba author Berbegal-Sáez, Paula author Lassalle, Olivier author Manzoni, Olivier author Valverde Granados, Olga author 2023-12-05T07:10:41Z 2023-12-05T07:10:41Z 2023 A single dose of cocaine abolishes endocannabinoid-mediated long-term depression (eCB-LTD) in the nucleus accumbens (NAc) within 24 h of administration. However, it is uncertain whether this altered neuroplasticity entails a behavioral deficit. As previously reported, after a single dose of cocaine (20 mg/kg), mice displayed impaired eCB-LTD in the NAc. Such cocaine-induced neuroplastic impairment was accompanied by an altered preference for saccharin and social interactions and a reduction in mRNA levels of the anandamide-catabolizing enzyme NAPE-PLD. The pharmacological increase of anandamide through the fatty acid amide hydrolase (FAAH) inhibitor URB597 (1 mg/kg) reversed the cocaine-induced loss of eCB-LTD in the NAc and restored normal social interaction in cocaine-exposed mice, but it did not affect saccharin preference. Overall, this research underlines the neuroplastic and behavioral alterations occurring after the initial use of cocaine and suggests a potential role for anandamide. This work was supported by the Ministerio de Ciencia e Innovación (#PID2019-104077RB-100 and #PID2022-136962OB-I00 MCIN/AEI/10.13039/501100011033), Ministerio de Sanidad (Government Delegation for the Plan National on Drugs corresponding to Recovery Mechanism Funds, Transformation and Resilience (PRTR) of the European Union #EXP2022/00869, and ISCIII-Feder-RIAPAd-RICORS #RD21/0009/001), the Generalitat de Catalunya, AGAUR (#2021SGR00485) and by the Institut National de la Santé et de la Recherche Médicale (INSERM). L.A-Z received a FPI grant (BES-2017-080066). P.B-S received a FI-AGAUR grant from the Generalitat de Catalunya (2021FI_B00205). The Department of Medicine and Health Sciences (UPF) is a “Unidad de Excelencia María de Maeztu” funded by the AEI (#CEX2018-000792-M). O.V. is recipient of an ICREA Academia Award (Institució Catalana de Recerca i Estudis Avançats, Generalitat de Catalunya. Motivation Reward Synaptic plasticity Cocaine-induced loss of LTD and social impairments are restored by fatty acid amide hydrolase inhibition