2026-04-17T23:36:01Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/579562025-12-12T02:18:56Zcom_2072_6col_2072_452952

Association of occupational heat exposure and colorectal cancer in the MCC-Spain study Hinchliffe, Alice Kogevinas, Manolis Molina, Antonio J. Moreno, Víctor Aragonés, Núria Castaño Vinyals, Gemma Jiménez Moleón, José Juan Gómez-Acebo, Inés Ederra, María Amiano, Pilar Molina-Barceló, Ana Fernandez-Tardon, Guillermo Alguacil Ojeda, Juan Chirlaque, María Dolores Hernández-Segura, Natalia Pérez-Gómez, Beatriz Pollán, Marina Turner, Michelle C. Carcinogenesis Colorectal cancer Health effect Heat exposure Heat stress MCC-Spain study Occupational health Occupational heat exposure Temperature Worker Objective: Heat exposure and heat stress/strain is a concern for many workers. There is increasing interest in potential chronic health effects of occupational heat exposure, including cancer risk. We examined potential associations of occupational heat exposure and colorectal cancer (CRC) risk in a large Spanish multi-case--control study. Methods: We analyzed data on 1198 histologically confirmed CRC cases and 2690 frequency-matched controls. The Spanish job-exposure matrix, MatEmEsp, was used to assign heat exposure estimates to the lifetime occupations of participants. Three exposure indices were assessed: ever versus never exposed, cumulative exposure and duration (years). We estimated odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression adjusting for potential confounders. Results: Overall, there was no association of ever, compared with never, occupational heat exposure and CRC (OR 1.09, 95% CI 0.92-1.29). There were also no associations observed according to categories of cumulative exposure or duration, and there was no evidence for a trend. There was no clear association of ever occupational heat exposure and CRC in analysis conducted among either men or women when analyzed separately. Positive associations were observed among women in the highest categories of cumulative exposure (OR 1.81, 95% CI 1.09-3.03) and duration (OR 2.89, 95% CI 1.50-5.59) as well as some evidence for a trend (P<0.05). Conclusion: Overall, this study provides no clear evidence for an association between occupational heat exposure and CRC. 2023-09-26T06:31:28Z 2023-09-26T06:31:28Z 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Scand J Work Environ Health. 2023;49(3):211-21 This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Nordic Association of Occupational Safety and Health (NOROSH)