2026-04-14T06:18:34Zhttps://recercat.cat/oai/request
oai:recercat.cat:10230/573502025-12-24T08:43:58Zcom_2072_6col_2072_452952
RECERCAT author Arismendi, Ebymar author Rivas, Eva author Vidal Alaball, Josep author Barreiro Portela, Esther author Torralba, Yolanda author Burgos, Felip author Rodríguez-Roisin, Robert 2023-06-27T06:11:07Z2023-06-27T06:11:07Z2015 The relationship between airway hyperresponsiveness (AHR) and obesity, a low-grade systemic inflammatory condition, remains largely unknown. It is established that AHR to indirect stimuli is associated with active airway inflammation. The objectives were to investigate the rate of AHR to mannitol in obese subjects and its changes 1 year after bariatric surgery (BS). We enrolled 58 candidates to BS severely obese (33 nonsmokers and 25 smokers) without history of asthma and 20 healthy, nonobese participants and related AHR to functional findings and serum and exhaled biomarkers. Before surgery, AHR was observed in 16 (28 %) obese with the provocation doses of mannitol to induce a 15 % fall in FEV1 (PD15) of (geometric mean [95 % CI]) 83 (24–145) mg. Compared to control participants, obese participants had lower spirometric values and higher serum and exhaled biomarkers (p < 0.05 each). After surgery, AHR was abolished (p < 0.01) in all but four obese subjects. Weight loss induced by BS was the key independent factor associated to AHR improvement. AHR to mannitol is highly prevalent in obesity, and it is largely abolished by BS. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. http://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/openAccess Abdominal obesity Airway inflammation Bronchial hyperreactivity Indirect bronchoconstrictor Systemic inflammation Airway hyperresponsiveness to mannitol in obesity before and after bariatric surgery info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion