2026-04-17T04:08:58Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/564482025-12-18T01:13:22Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Aparisi, Álvaro author Martín-Fernández, Marta author Ybarra-Falcón, Cristina author Gil, José Francisco author Carrasco-Moraleja, Manuel author Martínez-Paz, Pedro author Cusácovich, Iván author Gonzalo-Benito, Hugo author Fuertes, Raúl author Marcos-Mangas, Marta author Iglesias-Echeverría, Carolina author San Román, J. Alberto author Tamayo Aguirre, Eduardo author Andaluz Ojeda, David author Tamayo-Velasco, Álvaro author 2023-04-12T06:10:47Z 2023-04-12T06:10:47Z 2022 Recent works have demonstrated a significant reduction in cholesterol levels and increased oxidative stress in patients with coronavirus disease 2019 (COVID-19). The cause of this alteration is not well known. This study aimed to comprehensively evaluate their possible association during the evolution of COVID-19. This is an observational prospective study. The primary endpoint was to analyze the association between lipid peroxidation, lipid, and inflammatory profiles in COVID-19 patients. A multivariate regression analysis was employed. The secondary endpoint included the long-term follow-up of lipid profiles. COVID-19 patients presented significantly lower values in their lipid profile (total, low, and high-density lipoprotein cholesterol) with greater oxidative stress and inflammatory response compared to the healthy controls. Lipid peroxidation was the unique oxidative parameter with a significant association with the total cholesterol (OR: 0.982; 95% CI: 0.969-0.996; p = 0.012), IL1-RA (OR: 0.999; 95% CI: 0.998-0.999; p = 0.021) IL-6 (OR: 1.062; 95% CI: 1.017-1.110; p = 0.007), IL-7 (OR: 0.653; 95% CI: 0.433-0.986; p = 0.042) and IL-17 (OR: 1.098; 95% CI: 1.010-1.193; p = 0.028). Lipid abnormalities recovered after the initial insult during long-term follow-up (IQR 514 days); however, those with high LPO levels at hospital admission had, during long-term follow-up, an atherogenic lipid profile. Our study suggests that oxidative stress in COVID-19 is associated with derangements of the lipid profile and inflammation. Survivors experienced a recovery in their lipid profiles during long-term follow-up, but those with stronger oxidative responses had an atherogenic lipid profile. COVID-19 Inflammation Lipid peroxidation Lipoproteins Oxidative stress Total cholesterol Dyslipidemia and inflammation as hallmarks of oxidative stress in COVID-19: A follow-up study