2026-04-14T03:35:45Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/560702025-12-18T01:11:50Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Hernández Fernández, Carlos Pelayo author Giménez Arnau, Anna Maria author García-Doval, Ignacio author 2023-03-07T08:00:20Z 2023-03-07T08:00:20Z 2022 Background: current frequency and risk factors for sensitization to methylisothiazolinone (MI), methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), benzisothiazolinone (BIT) and octylisothiazolinone (OIT) in Spain are not well known. Objectives: to study the frequency of sensitization, risk factors and simultaneous sensitization between the four isothiazolinones. Materials and methods: we analysed all 2019-2021 consecutive patients patch-tested with MI (0.2% aq.), MCI/MI (0.02% aq.), BIT (0.1% pet.) and OIT (0.1% pet) within the Spanish Contact Dermatitis Registry (REIDAC). Results: a total of 2511 patients were analysed. Frequencies of sensitization were: any isothiazolinone 15.7%, MI 6.8%, MCI/MI 4.8%, BIT 3.5% and OIT 0.5%. MI and MCI/MI sensitization was associated with being occupationally active, hand dermatitis, detergents and age over 40. BIT sensitization was associated with leg dermatitis and age over 40. About one in nine MI-positive patients were positive to BIT, whereas one in five BIT-positive patients were positive to MI. Conclusions: sensitization to MI, MCI/MI and BIT is still common in Spain, while sensitization to OIT is rare. Currently, sensitization to MI and MCI/MI seems to be occupationally related. Although its origin is unknown, sensitization to BIT is more frequent in patients aged over 40 years. Simultaneous sensitization between MI and BIT is uncommon. Spain Benzisothiazolinone Contact dermatitis Methylchloroisothiazolinone/methylisothiazolinone Methylisothiazolinone Octylisothiazolinone Patch tests Standard series Sensitization to isothiazolinones in the Spanish Contact Dermatitis Registry (REIDAC). 2019-2021 epidemiological situation