2026-04-13T14:23:37Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/560092025-12-18T01:18:17Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Talló Parra, Marc, 1992- author Muscolino, Elena author Díez Antón, Juana, 1962- author 2023-03-02T07:05:37Z 2023-03-02T07:05:37Z 2022 Viruses completely depend on the host translation machineries to express the viral proteins. Recent data reveal an unprecedented interaction of positive strand RNA ((+)RNA) viruses with the host tRNA epitranscriptome to favor viral protein expression via a specific reprogramming of codon optimality that ultimately favors decoding of the viral codons. We propose that this feature is shared by multiple RNA viruses and that the involved tRNA modifying enzymes represent promising novel targets for the development of broad-spectrum antivirals. This work was supported by the Spanish Ministry of Economy, Industry and Competitiveness (AEI/MINECO/FEDER, UE; PID2019-106959RB-I00) and the “Unidad de Excelencia María de Maeztu” funded by the AEI (CEX2018-000792-M). tRNA tRNA modifications tRNA epitranscriptome (+)RNA viruses CHIKV KIAA1456 Viruses Codon usage The host tRNA epitranscriptome: A new player in RNA virus infections