2026-04-17T05:55:36Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/552772025-12-13T21:21:34Zcom_2072_6col_2072_452952

urn:hdl:10230/55277 Periodic spatial patterning with a single morphogen Wang, Sheng-Yue García Ojalvo, Jordi Elowitz, Michael B. Pattern formation Reaction-diffusion Single morphogen During multicellular development, periodic spatial patterning systems generate repetitive structures, such as digits, vertebrae, and teeth. Turing patterning provides a foundational paradigm for understanding such systems. The simplest Turing systems are believed to require at least two morphogens to generate periodic patterns. Here, using mathematical modeling, we show that a simpler circuit, including only a single diffusible morphogen, is sufficient to generate long-range, spatially periodic patterns that propagate outward from transient initiating perturbations and remain stable after the perturbation is removed. Furthermore, an additional bistable intracellular feedback or operation on a growing cell lattice can make patterning robust to noise. Together, these results show that a single morphogen can be sufficient for robust spatial pattern formation and should provide a foundation for engineering pattern formation in the emerging field of synthetic developmental biology. This research was supported by the Allen Discovery Center program under award no. UWSC10142, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation. J.G.-O. was supported by the Spanish Ministry of Science and Innovation and FEDER, under project PGC2018-101251-B-I00, by the “Maria de Maeztu” Programme for Units of Excellence in R&D (grant CEX2018-000792-M), and by the Generalitat de Catalunya. We acknowledge insightful feedback from Elowitz lab members. 2023-01-16T07:34:38Z 2023-01-16T07:34:38Z 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cell Syst. 2022 Dec 21;13(12):1033-47.e7 info:eu-repo/grantAgreement/ES/2PE/PGC2018-101251-B-I00 © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Elsevier