2026-04-18T07:27:17Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/550822025-12-24T08:29:21Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Moreno-Ramos, Manuel José author Sánchez-Piedra, Carlos author Martínez-González, Olga author Rodríguez-Lozano, Carlos author Pérez-García, Carolina author Freire, Mercedes author Campos, Cristina author Cáliz-Caliz, Rafael author Calvo, Jerusalem author Blanco-Madrigal, Juan M. author Pérez-Gómez, Ana author Moreno-Martínez, María José author Linares, Luis author Sánchez-Alonso, Fernando author Sastré, Carlos author Castrejón, Isabel author 2022-12-05T08:03:43Z 2022-12-05T08:03:43Z 2022 Rheumatic diseases are extensively managed with biological disease-modifying antirheumatic drugs (bDMARDs), but a notable proportion of patients withdraw in the long term because of lack of effectiveness, adverse events, or the patient's decision. The present real-world analysis showed the effectiveness, retention, and safety data collected in the Spanish BIOBADASER registry for patients with psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA, including ankylosing spondylitis (AS) and non-radiographic axSpA) treated with secukinumab, a human antibody against interleukin-17A (IL-17A), for more than 12 months. Six hundred and thirty-nine patients were analysed (350, 262, and 27 PsA, AS, and nr-axSpA patients, respectively). The results showed an improvement in the disease activity after 1 year of treatment, in terms of decreases of the mean Disease Activity Score 28 using C-reactive protein (DAS28-CRP), the mean Disease Activity Psoriatic Arthritis (DAPSA) score, swollen joint counts (SJC), and tender joint counts (TJC) in PsA patients and decreases in the mean Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the mean Ankylosing Spondylitis Disease Activity Score (ASDAS) in axSpA patients. This improvement was maintained or increased after 2 and 3 years of treatment, indicating that secukinumab is effective in both naïve and non-responder patients. Retention rates were higher when secukinumab was used as the first-line biological treatment, although they were also adequate in the second and third lines of treatment. Collected safety data were consistent with previous reports. Ankylosing spondylitis Axial spondyloarthritis IL-17 Non-radiographic axial spondyloarthrtis Psoriatic arthritis Secukinumab Real-world effectiveness and treatment retention of secukinumab in patients with psoriatic arthritis and axial spondyloarthritis: a descriptive observational analysis of the spanish BIOBADASER registry