2026-04-14T05:09:06Zhttps://recercat.cat/oai/request
oai:recercat.cat:10230/548502025-12-20T16:57:47Zcom_2072_6col_2072_452952
RECERCAT author Solà Porta, Eulàlia author Redondo Pachón, María Dolores author Arias Cabrales, Carlos Enrique author Navazo, Diego author Buxeda, Anna author Burballa Tàrrega, Carla, 1988- author Crespo Barrio, Marta author García Retortillo, Montserrat author Pascual Santos, Julio author Pérez-Sáez, María José 2022-11-15T08:29:37Z2022-11-15T08:29:37Z2021 Early hypertransaminasemia after kidney transplantation (KT) is frequent. It has been associated with the crosstalk produced between the liver and the kidney in ischemia-reperfusion situations. However, the influence of the donor type has not been evaluated. We present a retrospective study analyzing the increase in serum aspartate aminotransferase/alanine aminotransferase (AST/ALT) during the first three months post-KT in 151 recipients who received thymoglobulin as induction therapy, either from brain-death donors (DBD, n = 75), controlled circulatory death donors (cDCD, n = 33), or uncontrolled DCD (uDCD, n = 43). Eighty-five KT recipients from DBD who received basiliximab were included as controls. From KT recipients who received thymoglobulin, 33.6/43.4% presented with an increase in AST/ALT at 72 h post-KT, respectively. Regarding donor type, the percentage of recipients who experienced 72 h post-KT hypertransaminasemia was higher in uDCD group (65.1/83.7% vs. 20.3/26% in DBD and 20.7/27.6% in cDCD, p < 0.001). Within the control group, 9.4/12.9% of patients presented with AST/ALT elevation. One month after transplant, AST/ALT values returned to baseline in all groups. The multivariate analysis showed that uDCD recipients had 6- to 12-fold higher risk of developing early post-KT hypertransaminasemia. Early post-KT hypertransaminasemia is a frequent and transient event related to the kidney donor type, being more frequent in uDCD recipients. Copyright © 2021 by Solà-Porta E, Redondo-Pachón D, Arias-Cabrales C, Navazo D, Buxeda A, Burballa C, et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Donor after circulatory death Early Hypertransaminasemia Kidney transplantation Transaminases Early hypertransaminasemia after kidney transplantation: significance and evolution according to donor type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion