2026-04-14T04:45:57Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/548502025-12-20T16:57:47Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Solà Porta, Eulàlia author Redondo Pachón, María Dolores author Arias Cabrales, Carlos Enrique author Navazo, Diego author Buxeda, Anna author Burballa Tàrrega, Carla, 1988- author Crespo Barrio, Marta author García Retortillo, Montserrat author Pascual Santos, Julio author Pérez-Sáez, María José author 2022-11-15T08:29:37Z 2022-11-15T08:29:37Z 2021 Early hypertransaminasemia after kidney transplantation (KT) is frequent. It has been associated with the crosstalk produced between the liver and the kidney in ischemia-reperfusion situations. However, the influence of the donor type has not been evaluated. We present a retrospective study analyzing the increase in serum aspartate aminotransferase/alanine aminotransferase (AST/ALT) during the first three months post-KT in 151 recipients who received thymoglobulin as induction therapy, either from brain-death donors (DBD, n = 75), controlled circulatory death donors (cDCD, n = 33), or uncontrolled DCD (uDCD, n = 43). Eighty-five KT recipients from DBD who received basiliximab were included as controls. From KT recipients who received thymoglobulin, 33.6/43.4% presented with an increase in AST/ALT at 72 h post-KT, respectively. Regarding donor type, the percentage of recipients who experienced 72 h post-KT hypertransaminasemia was higher in uDCD group (65.1/83.7% vs. 20.3/26% in DBD and 20.7/27.6% in cDCD, p < 0.001). Within the control group, 9.4/12.9% of patients presented with AST/ALT elevation. One month after transplant, AST/ALT values returned to baseline in all groups. The multivariate analysis showed that uDCD recipients had 6- to 12-fold higher risk of developing early post-KT hypertransaminasemia. Early post-KT hypertransaminasemia is a frequent and transient event related to the kidney donor type, being more frequent in uDCD recipients. Donor after circulatory death Early Hypertransaminasemia Kidney transplantation Transaminases Early hypertransaminasemia after kidney transplantation: significance and evolution according to donor type