2026-04-13T06:49:49Zhttps://recercat.cat/oai/requestoai:recercat.cat:10230/546042025-12-23T20:53:39Zcom_2072_6col_2072_452954
RECERCAT
author
Font Murillo, Mònica
2022-10-26T13:32:05Z2022-10-26T13:32:05Z2022
Tutors: Andy L.Olivares, Jordi Mill TenaTreball de fi de grau en BiomèdicaTranscatheter aortic valve implantation (TAVI) is a minimally invasive heart procedure
that has emerged as a safe and effective treatment for patients with symptomatic aortic
stenosis. However, there remain important challenges to improve patient outcomes, such
as device-related thrombosis (DRT). Although there are some potential factors underlying
thrombosis described by Virchow’s triad, DRT’s onset after this intervention is poorly
understood. Computational methods can provide more information to understand why
this happens, and help predict the occurrence of thrombosis. The objective of this
Bachelor Thesis (BT) was to develop a computational workflow to evaluate TAVI
thrombosis risk under patient-specific conditions by CFD simulations.
The data of two patients, one with DRT and the other one healthy, both with transcatheter
aortic valves implanted were provided by Montreal Heart Institute (Montreal, Canada).
The methodological process involved: the (i) segmentation and reconstruction of
computed tomography (CT) images; (ii) the interaction between the device and the
anatomy; (iii) the discretization of all TAVI components; (iv) the set-up of the material
properties and boundary conditions in fluid dynamic simulation and (v) the calculation of
haemodynamic indices to assess the risk of thrombus formation.
The results obtained on the healthy control and the DRT patient showed significant
differences which were consistent with the area where the thrombus was found, leading
to some relevant conclusions to set the basis for future works regarding the TAVI
modeling for the prediction of DRT.
©Tots els drets reservats info:eu-repo/semantics/openAccess
Transcatheter aortic valve implantation (TAVI)
Device related thrombosis (DRT)
Computational fluid dynamics (CFD)
In-silico study of the device-related thrombosis after transcatheter aortic valve implantation
info:eu-repo/semantics/bachelorThesis