2026-04-17T06:05:15Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/545942025-12-18T01:10:55Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Gil Solsona, Rubén author Nika, Maria-Christina author Bustamante Pineda, Mariona author Villanueva Belmonte, Cristina author Foraster Pulido, Maria, 1984- author Cosín Tomàs, Marta author Alygizakis, Nikiforos author Gómez-Roig, María Dolores author Llurba, Elisa author Sunyer Deu, Jordi author Thomaidis, Nikolaos S. author Dadvand, Payam author Gago Ferrero, Pablo author 2022-10-26T07:09:25Z 2022-10-26T07:09:25Z 2021 Chemicals are part of our daily lives, and we are exposed to numerous chemicals through multiple pathways. Relevant scientific evidence contributing to the regulation of hazardous chemicals require a holistic approach to assess simultaneous exposure to multiple compounds. Biomonitoring provides an accurate estimation of exposure to chemicals through very complex and costly sampling campaigns. Finding efficient proxies to predict the risk of chemical exposure in humans is an urgent need to cover large areas and populations at a reasonable cost. We conducted an exploratory study to characterize the human chemical exposome in maternal blood and placenta samples of a population-based birth cohort in Barcelona (2018-2021). Ultimate HRMS-based approaches were applied including wide-scope target, suspect, and nontarget screening. Forty-two chemicals were identified including pesticides, personal care products, or industrial compounds, among others, in the range of ng/mL and ng/g. In parallel, sewage sludge from the wastewater treatment plants serving the residence areas of the studied population were also screened, showing correlations with the type and concentrations of chemicals found in humans. Our findings were suggestive for the potential use of sewage sludge as a proxy of the human exposure and its application in early warning systems to prevent bioaccumulation of hazardous chemicals. This work received support from the “La Caixa” Foundation (ID 100010434), fellowship code LCF/BQ/PR20/11770013, and Barcelona Council (Expo-Bar). The BiSC cohort study is funded by the European Research Council (ERC) under Grant Agreement No. 785994 (AIR-NB), and the Health Effects Institute (HEI) with Grant Agreement No. 4959-RFPA15-1/18-1 (FRONTIER). IDAEA-CSIC and ISGlobal are Centres of Excellence Severo Ochoa (Spanish Ministry of Science and Innovation). Productes químics Medi ambient Contaminants The potential of sewage sludge to predict and evaluate the human chemical exposome