2026-04-17T11:31:39Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/525322025-12-18T01:06:13Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Huang, Yan author Sanz, Javier author Rodríguez de Dios, Núria author Duran Jordà, Xavier, 1974- author Martínez, Álvaro author Li, X. author Foro Arnalot, Palmira author Conde, M. author Zhao, Mengyao author Liu, F. author Reig Castillejo, Anna author Dengra, Josefa author Membrive, Ismael author Pérez, P. author Algara López, Manuel-Ignacio author 2022-02-21T08:03:17Z 2022-02-21T08:03:17Z 2022 Purpose: Radiation-induced toxicity (RIT) is usually assessed by inspection and palpation. Due to their subjective and unquantitative nature, objective methods are required. This study aimed to determine whether a quantitative tool is able to assess RIT and establish an underlying BED-response relationship in breast cancer. Methods: Patients following seven different breast radiation protocols were recruited to this study for RIT assessment with qualitative and quantitative examination. The biologically equivalent dose (BED) was used to directly compare different radiation regimens. RIT was subjectively evaluated by physicians using the Radiation Therapy Oncology Group (RTOG) late toxicity scores. Simultaneously an objective multiprobe device was also used to quantitatively assess late RIT in terms of erythema, hyperpigmentation, elasticity and skin hydration. Results: In 194 patients, in terms of the objective measurements, treated breasts showed higher erythema and hyperpigmentation and lower elasticity and hydration than untreated breasts (p < 0.001, p < 0.001, p < 0.001, p = 0.019, respectively). As the BED increased, Δerythema and Δpigmentation gradually increased as well (p = 0.006 and p = 0.002, respectively). Regarding the clinical assessment, the increase in BED resulted in a higher RTOG toxicity grade (p < 0.001). Quantitative assessments were consistent with RTOG scores. As the RTOG toxicity grade increased, the erythema and pigmentation values increased, and the elasticity index decreased (p < 0.001, p = 0.016, p = 0.005, respectively). Conclusions: The multiprobe device can be a sensitive and simple tool for research purpose and quantitatively assessing RIT in patients undergoing radiotherapy for breast cancer. Physician-assessed toxicity scores and objective measurements revealed that the BED was positively associated with the severity of RIT. Biological equivalent dose Breast cancer Objective evaluation Quantitative assessment Radiation-induced toxicity Radiotherapy Quantitative assessments of late radiation-induced skin and soft tissue toxicity and correlation with RTOG scales and biological equivalent dose in breast cancer