2026-04-13T16:55:14Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/492092025-12-12T02:12:36Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Everson, Todd M. author Vives Usano, Marta, 1990- author Sunyer Deu, Jordi author Bustamante Pineda, Mariona author 2021-12-15T07:28:43Z 2021-12-15T07:28:43Z 2021 Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth. This work was supported by the National Institutes of Health [NIH-NIMH R01MH094609, NIH-NIEHS R01ES022223]. It is supported by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (ZO1 ES49019). And also by the National Institutes of Health [NIH-NIMH R01MH094609, NIH-NIEHS R01ES022223 and the Intramural Research Program of the NIH-NIEHS, ESZ0149019] Embarassades -- Consum de tabac Placenta Fetus -- Trastorns del creixement Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth