2026-04-13T13:45:13Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/490132025-12-19T20:29:06Zcom_2072_6col_2072_452954

00925njm 22002777a 4500 dc López Ruiz de Vargas, Sara author 2021-11-18T10:52:26Z 2021-11-18T10:52:26Z 2021 Treball de fi de grau en Bioinformàtica. Curs 2020-2021 Tutor: Trisevgeni Rapakoulia We applied an enhancer prediction method to an extensive set of epigenetic profiles from the ENCODE project. We identified enhancer elements in 104 human primary cells, cell lines, and tissues. This extensive generation of enhancer profiles allowed us to identify groups of cell types that are pretty similar in terms of enhancer usage and cell types that differ significantly. A case study on adult brain and embryo placenta tissues with quite different sets of active enhancers revealed cell-type specific enhancers that regulate the expression of genes linked to the tissue phenotype. Further exploitation of additional cell groups can reveal the lineage-specific enhancers. Treball de fi de grau – Curs 2020-2021 Amplificació gènica Anàlisi de dades de panel Regulació de la transcripció Amplificadores Análisis de datos Regulación de la transcripción Enhancers Data analysis Transcription regulation A comprehensive map of predicted enhancers on a large panel of human primary cells, cell lines and tissues