2026-04-17T12:49:48Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/489982025-12-20T16:50:38Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Maldonado, Rafael, 1961- author Calvé Pérez, Pablo, 1993- author García Blanco, Alejandra author Domingo Rodriguez, Laura, 1992- author Senabre, Eric author Martín García, Elena, 1975- author 2021-11-17T07:38:32Z 2021 Addiction is a chronic brain disease that has dramatic health and socioeconomic consequences worldwide. Multiple approaches have been used for decades to clarify the neurobiological basis of this disease and to identify novel potential treatments. This review summarizes the main brain networks involved in the vulnerability to addiction and specific innovative technological approaches to investigate these neural circuits. First, the evolution of the definition of addiction across the Diagnostic and Statistical Manual of Mental Disorders (DSM) is revised. We next discuss several innovative experimental techniques that, combined with behavioral approaches, have allowed recent critical advances in understanding the neural circuits involved in addiction, including DREADDs, calcium imaging, and electrophysiology. All these techniques have been used to investigate specific neural circuits involved in vulnerability to addiction and have been extremely useful to clarify the neurobiological basis of each specific component of the addictive process. These novel tools targeting specific brain regions are of great interest to further understand the different aspects of this complex disease. This article is part of the special issue on 'Vulnerabilities to Substance Abuse.'. This work was supported by the Spanish Ministerio de Economía y Competitividad-MINECO (#SAF2017-84060-R-AEI/FEDER-UE), the Spanish Instituto de Salud Carlos III, RETICS-RTA (#RD12/0028/0023), the Generalitat de Catalunya, AGAUR (#2017-SGR-669), ICREA-Acadèmia (#2015) and the Spanish Ministerio de Sanidad, Servicios Sociales e Igualdad, Plan NAcional Sobre Drogas of the Spanish Ministry of Health (#PNSD-2017I068) to R.M., Fundació La Marató-TV3 (#2016/20-30) and Plan NAcional Sobre Drogas of the Spanish Ministry of Health (#PNSD-2019I006) to E.M-G. Figures are created with BioRender.com. Addiction Calcium imaging DREADD DSM-5 Electrophysiology Inhibitory control Therapeutic approach Vulnerability to addiction