2026-04-17T11:56:20Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/489412026-01-28T14:08:41Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Domínguez-Andrés, Jorge author Kuijpers, Yunus author Bakker, Olivier B. author Jaeger, Martin author Xu, Cheng-Jian author van der Meer, Jos W.M. author Jakobsson, Mattias author Bertranpetit, Jaume, 1952- author Joosten, Leo A. B. author Li, Yang author Netea, Mihai G. author 2021-11-10T07:49:00Z 2021-11-10T07:49:00Z 2021 As our ancestors migrated throughout different continents, natural selection increased the presence of alleles advantageous in the new environments. Heritable variations that alter the susceptibility to diseases vary with the historical period, the virulence of the infections, and their geographical spread. In this study we built polygenic scores for heritable traits that influence the genetic adaptation in the production of cytokines and immune-mediated disorders, including infectious, inflammatory, and autoimmune diseases, and applied them to the genomes of several ancient European populations. We observed that the advent of the Neolithic was a turning point for immune-mediated traits in Europeans, favoring those alleles linked with the development of tolerance against intracellular pathogens and promoting inflammatory responses against extracellular microbes. These evolutionary patterns are also associated with an increased presence of traits related to inflammatory and auto-immune diseases. MGN was supported by an ERC Advanced Grant (833247) and a Spinoza Grant of the Netherlands Organization for Scientific Research. YL was supported by an ERC Starting Grant (948207) and the Radboud University Medical Centre Hypatia Grant (2018) for Scientific Research. JD-A is supported by The Netherlands Organization for Scientific Research (VENI grant 09150161910024). JB was supported by PID2019-110933GB-I00 (AEI/FEDER, UE) MINECO, Spain. Adaptation Disease Evolution Genetics Genomics Human Immune system Immunology Inflammation Neolithic Evolution of cytokine production capacity in ancient and modern European populations