2026-04-18T00:05:59Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/489392025-12-22T13:35:53Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Mañas García, Laura, 1991- author Denhard, Charlotte author Mateu de Antonio, Francisco Javier author Duran Jordà, Xavier, 1974- author Gea Guiral, Joaquim author Barreiro Portela, Esther author 2021-11-10T07:48:52Z 2021-11-10T07:48:52Z 2021 We hypothesized that the phenolic compound resveratrol mitigates muscle protein degradation and loss and improves muscle fiber cross-sectional area (CSA) in gastrocnemius of mice exposed to unloading (7dI). In gastrocnemius of mice (female C57BL/6J, 10 weeks) exposed to a seven-day period of hindlimb immobilization with/without resveratrol treatment, markers of muscle proteolysis (tyrosine release, systemic troponin-I), atrophy signaling pathways, and muscle phenotypic features and function were analyzed. In gastrocnemius of unloaded mice treated with resveratrol, body and muscle weight and function were attenuated, whereas muscle proteolysis (tyrosine release), proteolytic and apoptotic markers, atrophy signaling pathways, and myofiber CSA significantly improved. Resveratrol treatment of mice exposed to a seven-day period of unloading prevented body and muscle weight and limb strength loss, while an improvement in muscle proteolysis, proteolytic markers, atrophy signaling pathways, apoptosis, and muscle fiber CSA was observed in the gastrocnemius muscle. These findings may have potential therapeutic implications in the management of disuse muscle atrophy in clinical settings. Apoptosis Atrophy signaling pathways Chronic conditions Disuse muscle atrophy Limb muscles Muscle fiber cross-sectional areas Proteolysis Resveratrol Beneficial effects of resveratrol in mouse gastrocnemius: a hint to muscle phenotype and proteolysis