2026-04-13T06:37:33Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/486502025-12-26T11:22:51Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Farré Martínez, Adriana author Tirado Muñoz, Judit author Spataro, Nino author Alías i Ferri, María author Torrens, Marta author Fonseca Casals, Francina, 1972- author 2021-10-14T06:47:51Z 2021-10-14T06:47:51Z 2020 Background: In clinical practice, there is the need to have clinical and biological markers to identify induced depression. The objective was to investigate clinical, biological and genetic differences between Primary Major Depression (Primary MD) and Alcohol Induced MD (AI-MD). Methods: Patients, of both genders, were recruited from psychiatric hospitalisation units. The PRISM instrument was used to establish the diagnoses. Data on socio-demographic/family history, clinical scales for depression, anxiety, personality and stressful life events were recorded. A blood test was performed analysing biochemical parameters and a Genome Wide Association Study (GWAS) to identify genetic markers associated with AI-MD. Results: A total of 80 patients were included (47 Primary MD and 33 AI-MD). The AI-MD group presented more medical comorbidities and less family history of depression. There were differences in traumatic life events, with higher scores in the AI-MD (14.21 ± 11.35 vs. 9.30 ± 7.38; p = 0.021). DSM-5 criteria were different between groups with higher prevalence of weight changes and less anhedonia, difficulties in concentration and suicidal thoughts in the AI-MD. None of the genetic variants reached significance beyond multiple testing thresholds; however, some suggestive variants were observed. Conclusions: This study has found clinical and biological features that may help physicians to identify AI-MD and improve its therapeutic approach. This project has received funding from the European Union’s Horizon 2020 research and innovation programme 2014–2020 under Grant Agreement No. 634143 (MedBioinformatics) and ISCIII-Red de Trastornos Adictivos-RTA-FEDER (RD12/0028/0009 and RD16/0017/0010). Acció instrumental d’Intensificació de Professionals de la Salut—Facultatius especialistes (PERIS: SLT006/17/00014). GWAS Alcohol induced major depression Alcohol use disorder Biomarkers Clinical characteristics; comorbidity Primary major depression Alcohol induced depression: clinical, biological and genetic features