2026-04-17T17:20:49Zhttps://recercat.cat/oai/request
oai:recercat.cat:10230/473592025-12-20T16:59:25Zcom_2072_6col_2072_452952
RECERCAT author Chalouni, Mathieu author Rodríguez-Centeno, Javier author Samri, Assia author Blanco, Julian author Stella-Ascariz, Natalia author Wallet, Cedrick author Knobel Freud, Hernando author Zucman, David author Alejos Ferreras, Belen author Autran, Brigitte author Thiebaut, Rodolphe author Raffi, François author Arribas, José Ramón author NEAT001/ANRS143 Trial Study Group 2021-05-10T07:35:19Z2021-05-10T07:35:19Z2020 In 31 participants who started first-line antiretroviral therapy in the NEAT 001/ANRS 143 clinical trial, we found after 96 weeks a statistically significant increase in blood telomere length (TL) of 0.04 (T/S Ratio) (p = 0.03). This increase was positively correlated with both the change in the percentage of CD4+ T-cells and with the decrease of CD38+ molecules on Central Memory CD8+ and negatively correlated with the change in the percentage of CD4+ Effector Memory cells. Increase in TL could be an expression of immune reconstitution and the associated decrease in immune activation. We acknowledge for the low statistical power due to the small sample size and the potential for false positive results due to multiple testing. Hence, further studies are needed to confirm these observations. Copyright © 2020 Chalouni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/ which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess VIH (Virus) Immunologia ADP-ribosyl Cyclase 1 Antiretrovirals Limfòcits Recomendaciones en el manejo de la pandemia por coronavirus SARS-CoV-2 (Covid-19) en pacientes con trasplante renal Correlation between blood telomere length and CD4+ CD8+ T-cell subsets changes 96 weeks after initiation of antiretroviral therapy in HIV-1-positive individuals info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion