2026-04-17T22:50:47Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/470932025-12-20T16:43:02Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc de Jesús-Gil, Carmen author Sans-de San Nicolás, Lídia author Ruiz-Romeu, Ester author Ferran Farrés, Marta author Soria-Martinez, Laura author Chiriac, Anca author Celada, Antonio author Pujol Vallverdú, Ramon Maria author Santamaría-Babí, Luis Francisco author 2021-04-13T06:46:21Z 2020 Streptococcus pyogenes tonsillar infection is well known to trigger and exacerbate psoriasis lesions in both guttate and plaque forms of the disease. Although mucosal and cutaneous tissues are closely involved in psoriasis pathology, the interaction between their specific immune responses has not been deeply explored. This work aims to address and characterize the presence of humoral responses against S. pyogenes in patients with psoriasis and its putative association with cytokine responses detected in vitro in our psoriasis ex vivo model, based on the coculture of cutaneous lymphocyte-associated antigen+/- T cells with autologous epidermal cells. Patients with psoriasis presented increased IgA response to S. pyogenes when compared with control subjects. In patients with plaque psoriasis, despite being negative for anti-streptolysin O antibody titer, IgA plasma levels against S. pyogenes correlated with cutaneous lymphocyte-associated antigen+ T-cell-dependent IL-17F response in vitro. No association is observed for IgG levels in plaque psoriasis. Similar association is observed for IgA anti-S. pyogenes extract and IL-17A in patients with guttate psoriasis. We propose S. pyogenes-specific IgA as a potential new perspective for better understanding the role of S. pyogenes in psoriasis development. Psoriasi Estreptococs Streptococcus pyogenes extract Cutaneous lymphocyte antigen Phosphate buffered saline T helper type 17 Specific IgA and CLA + T-Cell IL-17 response to streptococcus pyogenes in psoriasis