2026-04-14T09:10:49Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/458452025-12-12T03:05:20Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Vosseberg, Julian author van Hooff, Jolien J.E. author Marcet Houben, Marina author van Vlimmeren, Anne author van Mijk, Leny M. author Gabaldón Estevan, Juan Antonio, 1973- author Snel, Berend author 2020-11-23T07:04:33Z 2021 Eukaryogenesis is one of the most enigmatic evolutionary transitions, during which simple prokaryotic cells gave rise to complex eukaryotic cells. While evolutionary intermediates are lacking, gene duplications provide information on the order of events by which eukaryotes originated. Here we use a phylogenomics approach to reconstruct successive steps during eukaryogenesis. We find that gene duplications roughly doubled the proto-eukaryotic gene repertoire, with families inherited from the Asgard archaea-related host being duplicated most. By relatively timing events using phylogenetic distances, we inferred that duplications in cytoskeletal and membrane-trafficking families were among the earliest events, whereas most other families expanded predominantly after mitochondrial endosymbiosis. Altogether, we infer that the host that engulfed the proto-mitochondrion had some eukaryote-like complexity, which drastically increased upon mitochondrial acquisition. This scenario bridges the signs of complexity observed in Asgard archaeal genomes to the proposed role of mitochondria in triggering eukaryogenesis. Timing the origin of eukaryotic cellular complexity with ancient duplications