2026-04-13T07:51:05Zhttps://recercat.cat/oai/requestoai:recercat.cat:10230/450632025-12-19T22:58:43Zcom_2072_6col_2072_452952
RECERCAT
author
Boronat Rigol, Anna, 1990-
author
Mateus Rodriguez, Julian Andrés
author
Soldevila-Domenech, Natalia
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Guerra Albà, Mercè
author
Rodríguez-Morató, Jose, 1987-
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Varon, Carlota
author
Muñoz, Daniel
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Barbosa, Francina
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Morales, Juan Carlos
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Gaedigk, Andreas
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Langohr, Klaus
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Covas Planells, Maria Isabel
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Pérez Mañá, Clara
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Fitó Colomer, Montserrat
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Tyndale, Rachel F.
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Torre Fornell, Rafael de la
2020-07-03T06:46:40Z2020-07-03T06:46:40Z2019
Here we present new and original data on the endogenous conversion of tyrosol (Tyr) into hydroxytyrosol (OHTyr) in humans and its effects on the cardiovascular system. A randomized, crossover, controlled clinical trial was performed with individuals at cardiovascular risk (n = 33). They received white wine (WW) (females 1, males 2 standard drinks/day), WW plus Tyr capsules (WW + Tyr) (25mg Tyr capsule, one per WW drink), and water (control) ad libitum. Intervention periods were of 4 weeks preceded by three-week wash-out periods. We assessed the conversion of Tyr to OHTyr, its interaction with a polygenic activity score (PAS) from CYP2A6 and CYP2D6 genotypes, and the effects on cardiovascular risk markers. For further details and experimental findings please refer to the article "Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans. A randomized, controlled trial"
© 2019 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
CYP2A6
CYP2D6
Cardiovascular risk
Endogenous conversion
Hydroxytyrosol
Tyrosol
Data on the endogenous conversion of tyrosol into hydroxytyrosol in humans
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion