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oai:recercat.cat:10230/449842025-12-12T02:39:03Zcom_2072_6col_2072_452952

The dietary inflammatory index and chronic lymphocytic leukaemia in the MCC Spain Study Flores, José Carlos Gracia Lavedan, Esther Romaguera Bosch, Dora Gimeno Vázquez, Eva Kogevinas, Manolis Castaño Vinyals, Gemma Casabonne, Delphine MCC Spain study Cancer Case-control study Chronic lymphocytic leukaemia Dietary inflammatory index Nutrition Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR T3vsT1: 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research. 2020-06-16T07:06:49Z 2020-06-16T07:06:49Z 2020 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Flores JC, Gracia-Lavedan E, Benavente Y, Amiano P, Romaguera D, Costas L, et al. The dietary inflammatory index and chronic lymphocytic leukaemia in the MCC Spain Study. Nutrients. 2019 Dec 23; 12(1):48. DOI: 10.3390/nu12010048 2072-6643 http://hdl.handle.net/10230/44984 http://dx.doi.org/10.3390/nu12010048 eng Nutrients. 2019 Dec 23;12(1):48 Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf application/pdf MDPI