2026-04-13T06:39:56Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/442632025-12-12T01:32:05Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium author Demidov, German, 1990- author Drechsel, Oliver author Ossowski, Stephan author Estivill, Xavier, 1955- author Escaramís, Geòrgia author Bosio, Mattia author Holik, Aliaksei Z. author Sušak, Hana, 1985- author Rabionet Janssen, Raquel author Stobbe, Miranda D. author Marquès i Bonet, Tomàs, 1975- author Navarro i Cuartiellas, Arcadi, 1969- author Gut, Ivo Glynne author Beltran, Sergi author Gut, Marta author Trotta, Jean-Remi author Whalley, Justin P. author Heath, Simon author Prasad, Aparna author Heredia Genestar, José María, 1985- author Sabarinathan, Radhakrishnan author Pich Roselló, Oriol, 1992- author Gonzalez-Perez, Abel author Rubio Pérez, Carlota, 1990- author Tamborero Noguera, David author Mularoni, Loris author Deu-Pons, Jordi author Muiños, Ferran author Muyas Remolar, Francesc, 1992- author 2020-04-17T07:01:12Z 2020-04-17T07:01:12Z 2020 Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale . Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation; analyses timings and patterns of tumour evolution; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity; and evaluates a range of more-specialized features of cancer genomes. Càncer Genòmica Genètica Pan-cancer analysis of whole genomes