2026-04-18T04:22:34Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/436202025-12-24T08:38:30Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Deco, Gustavo author Cruzat Grand, Josefina, 1983- author Cabral, Joana author Tagliazucchi, Enzo author Laufs, Helmut author Logothetis, Nikos author Kringelbach, Morten L. author 2020-02-17T15:51:07Z 2020-02-17T15:51:07Z 2019 A fundamental problem in systems neuroscience is how to force a transition from one brain state to another by external driven stimulation in, for example, wakefulness, sleep, coma, or neuropsychiatric diseases. This requires a quantitative and robust definition of a brain state, which has so far proven elusive. Here, we provide such a definition, which, together with whole-brain modeling, permits the systematic study in silico of how simulated brain stimulation can force transitions between different brain states in humans. Specifically, we use a unique neuroimaging dataset of human sleep to systematically investigate where to stimulate the brain to force an awakening of the human sleeping brain and vice versa. We show where this is possible using a definition of a brain state as an ensemble of “metastable substates,” each with a probabilistic stability and occurrence frequency fitted by a generative whole-brain model, fine-tuned on the basis of the effective connectivity. Given the biophysical limitations of direct electrical stimulation (DES) of microcircuits, this opens exciting possibilities for discovering stimulation targets and selecting connectivity patterns that can ensure propagation of DES-induced neural excitation, potentially making it possible to create awakenings from complex cases of brain injury. G.D. is supported by the Spanish Research Project PSI2016-75688-P (Agencia Estatal de Investigación/Fondo Europeo de Desarrollo Regional, European Union); by the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreements 720270 (Human Brain Project [HBP] SGA1) and 785907 (HBP SGA2); and by the Catalan Agency for Management of University and Research Grants Programme 2017 SGR 1545. J. Cabral is supported by Portuguese Foundation for Science and Technology CEECIND/03325/2017, Portugal. M.L.K. is supported by the European Research Council Consolidator Grant: CAREGIVING (615539) and Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117). Brain states Metastates Electrical stimulation Computational neuroscience Modeling Awakening: Predicting external stimulation to force transitions between different brain states