2026-04-14T07:04:07Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/369692025-12-26T11:21:28Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Gonzalez-Tendero, Anna author Zhang, Chong author Balicevic, Vedrana author Cárdenes, Rubén author Loncaric, Sven author Butakoff, Constantine author Paun, Bruno author Bonnin, Anne author Garcia Canadilla, Patricia author Muñoz-Moreno, Emma author Gratacós Solsona, Eduard author Crispi Brillas, Fàtima author Bijnens, Bart author 2019-03-26T11:02:01Z 2019-03-26T11:02:01Z 2017 While individual cardiac myocytes only have a limited ability to shorten, the heart efficiently pumps a large volume-fraction thanks to a cell organization in a complex 3D fibre structure. Subclinical subtle cardiac structural remodelling is often present before symptoms arise. Understanding and early detection of these subtle changes is crucial for diagnosis and prevention. Additionally, personalized computational modelling requires knowledge on the multi-scale structure of the whole heart and vessels. This study was partly supported by Ministerio de Economia y Competitividad (SAF2012-37196;TIN2014-52923-R); Instituto de Salud Carlos III (PI11/00051, PI11/01709, PI12/00801, PI14/00226) integrados en el Plan Nacional de I + D+I y cofinanciados por el ISCIII-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER) ‘Otra manera de hacer Europa’; the EU-FP7 for research, technological development and demonstration under grant agreement VP2HF (no611823); The Cerebra Foundation for the Brain Injured Child (Carmarthen, UK); Obra Social ‘la Caixa’ (Barcelona, Spain); Fundació Mutua Madrileña and Fundació Agrupació Mutua (Spain). Myocardial remodelling Myofibre structure Coronary vasculature Synchrotron phase-contrast CT Whole heart detailed and quantitative anatomy, myofibre structure and vasculature from X-ray phase-contrast synchrotron radiation-based micro computed tomography