2026-04-14T07:58:47Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/367982025-12-12T02:13:22Zcom_2072_6col_2072_452952

RNAct: Protein-RNA interaction predictions for model organisms with supporting experimental data Lang, Benjamin Armaos, Alexandros, 1989- Tartaglia, Gian Gaetano Protein-RNA interactions are implicated in a number of physiological roles as well as diseases, with molecular mechanisms ranging from defects in RNA splicing, localization and translation to the formation of aggregates. Currently, ∼1400 human proteins have experimental evidence of RNA-binding activity. However, only ∼250 of these proteins currently have experimental data on their target RNAs from various sequencing-based methods such as eCLIP. To bridge this gap, we used an established, computationally expensive protein-RNA interaction prediction method, catRAPID, to populate a large database, RNAct. RNAct allows easy lookup of known and predicted interactions and enables global views of the human, mouse and yeast protein-RNA interactomes, expanding them in a genome-wide manner far beyond experimental data (http://rnact.crg.eu). European Research Council [RIBOMYLOME_309545]; European Union's Horizon 2020 research and innovation programme [727658, IASIS]; Spanish Ministry of Economy and Competitiveness [BFU2014-55054-P, BFU2017-86970-P]; Spanish Ministry of Economy and Competitiveness; ‘Centro de Excelencia Severo Ochoa 2013-2017’; CERCA Programme of the Generalitat de Catalunya; Marie Sklodowska-Curie Individual Fellowship from the European Union's Horizon 2020 research and innovation programme (793135, ‘DeepRNA’ to B.L.). Funding for open access charge: European Research Council [RIBOMYLOME_309545], European Union [793135]. 2019-03-12T08:41:01Z 2019-03-12T08:41:01Z 2019 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Nucleic Acids Research. 2019; 47(D1):601-6 info:eu-repo/grantAgreement/ES/1PE/BFU2014-55054-P info:eu-repo/grantAgreement/EC/FP7/309545 info:eu-repo/grantAgreement/EC/H2020/727658 info:eu-repo/grantAgreement/EC/H2020/793135 © The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Oxford University Press