2026-04-14T05:04:39Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/367962026-01-23T20:22:03Zcom_2072_6col_2072_452952

urn:hdl:10230/36796 Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: insights from an observational cohort study González-Costello, José Comín Colet, Josep Lupón, Josep Enjuanes Grau, Cristina Antonio, Marta de Fuentes, Lara Moliner Borja, Pedro Farré López, Núria Zamora, Elisabet Manito Lorite, Nicolás Pujol Vallverdú, Ramon Maria Bayes-Genis, Antoni Malalts hospitalitzats Aliments--Contingut en ferro Infart Mortalitat Chronic heart failure Hospitalization Iron deficiency Mortality BACKGROUND: Iron deficiency (ID) in patients with chronic heart failure (CHF) is considered an adverse prognostic factor. We aimed to evaluate if ID in patients with CHF is associated with increased mortality and hospitalizations. METHODS: We evaluated ID in patients with CHF at 3 university hospitals. ID was defined as absolute (ferritin < 100 μg/L) or functional (transferrin Saturation index < 20% and ferritin between 100 and 299 μg/L). We excluded patients who received treatment with intravenous Iron or Erythropoietin during follow-up. We evaluated if ID was a predictor of death or hospitalization due to heart failure or any cause using univariate and multivariate cox regression analysis. RESULTS: We included 1684 patients, 65% males, 38% diabetics, median age of 72 years, 37% in functional class III-IV and 30% of patients with a left ventricular ejection fraction > 45%. Patients were well treated, with 87% and 88% of patients receiving renin-angiotensin inhibitors and beta-blockers, respectively. Median transferrin saturation index was 20%, median ferritin 155 ng/mL and median haemoglobin 13 g/dL. ID was present in 53% of patients; in 35% it was absolute and in 18% functional. Median follow-up was 20 months. ID was a predictor of death, hospitalization due to heart failure or to any cause in univariate analysis but not after multivariate analysis. No differences were found between absolute or functional ID regarding prognosis. CONCLUSION: In a real life population of patients with CHF and a high prevalence of heart failure with preserved ejection fraction, ID did not predict mortality or hospitalizations after adjustment for comorbidities, functional class and neurohormonal treatment. 2019-03-12T08:40:19Z 2019-03-12T08:40:19Z 2018 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion BMC Cardiovascular Disorders. 2018 Nov 1;18(1):206 © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess BioMed Central