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oai:recercat.cat:10230/366852025-12-21T18:08:45Zcom_2072_6col_2072_452952

Coffee consumption, genetic susceptibility and bladder cancer risk Villanueva, Cristina M. Silverman, Debra T. Murta-Nascimento, Cristiane Malats i Riera, Núria García Closas, Montserrat Castro Domínguez, Francisco Tardón, Adonina García Closas, Reina Serra, Consol Carrato, Alfredo Rothman, Nathaniel Real, Francisco X. Dosemeci, Mustafa Kogevinas, Manolis Bladder cancer Coffee Genetic susceptibility Epidemiology Objective: We evaluated the bladder cancer risk associated with coffee consumption in a case–control study in Spain and examined the gene–environment interactions for genetic variants of caffeine-metabolizing enzymes. Methods: The analyses included 1,136 incident cases with urothelial carcinoma of the urinary bladder and 1,138 controls. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for area, age, gender, amount of cigarette smoking, and years since quitting among former smokers. Results: The OR (95% CI) for ever consumed coffee was 1.25 (0.95–1.64). For consumers of 1, 2, 3, and 4 or more cups/day relative to never drinkers, OR were, respectively, 1.24 (0.92–1.66), 1.11 (95% CI 0.82–1.51), 1.57 (1.13–2.19), and 1.27 (0.88–1.81). Coffee consumption was higher in smokers compared to never smokers. The OR for drinking at least 4 cups/day was 1.13 (0.61–2.09) in current smokers, 1.57 (0.86–2.90) in former smokers, and 1.23 (0.55–2.76) in never smokers. Gene–coffee interactions evaluated in NAT2, CYP1A2, and CYP2E1-02 and CYP1A1 were not identified after adjusting for multiple testing. Conclusion: We observed a modest increased bladder cancer risk among coffee drinkers that may, in part, be explained by residual confounding by smoking. The findings from the gene–coffee interactions need replication in further studies. 2019-02-27T10:08:47Z 2019-02-27T10:08:47Z 2009 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Villanueva CM, Silverman DT, Murta-Nascimento C, Malats N, Garcia-Closas M, Castro F et al. Coffee consumption, genetic susceptibility and bladder cancer risk. Cancer Causes Control. 2009;20(1):121-7. DOI: 10.1007/s10552-008-9226-6 0957-5243 http://hdl.handle.net/10230/36685 http://dx.doi.org/10.1007/s10552-008-9226-6 eng Cancer Causes and Control. 2009;20(1):121-7 © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s10552-008-9226-6. info:eu-repo/semantics/openAccess application/pdf application/pdf Springer