2026-04-17T07:32:33Zhttps://recercat.cat/oai/request
oai:recercat.cat:10230/356762025-12-18T01:18:08Zcom_2072_6col_2072_452952
RECERCAT author Soria, Ivana author Quattrocchi, Valeria author Langellotti, Cecilia author Pérez-Filgueira, Mariano author Pega, J. author Gnazzo, V. author Romera, S. author Schammas, J. author Bucafusco, D. author Di Giacomo, S. author Torre, Beatriz G. de la author Andreu Martínez, David author Sobrino, Francisco author Blanco, Esther author Zamorano, Patricia 2018-10-30T13:19:09Z2018-10-30T13:19:09Z2018 Synthetic peptides mimicking protective B- and T-cell epitopes are good candidates for safer, more effective FMD vaccines. Nevertheless, previous studies of immunization with linear peptides showed that they failed to induce solid protection in cattle. Dendrimeric peptides displaying two or four copies of a peptide corresponding to the B-cell epitope VP1 [136-154] of type O FMDV (O/UKG/11/2001) linked through thioether bonds to a single copy of the T-cell epitope 3A [21-35] (termed B2T and B4T, resp.) afforded protection in vaccinated pigs. In this work, we show that dendrimeric peptides B2T and B4T can elicit specific humoral responses in cattle and confer partial protection against the challenge with a heterologous type O virus (O1/Campos/Bra/58). This protective response correlated with the induction of specific T-cells as well as with an anamnestic antibody response upon virus challenge, as shown by the detection of virus-specific antibody-secreting cells (ASC) in lymphoid tissues distal from the inoculation pointWork at INTA was supported by the National Institute of Agricultural Technology (Grant no. PNSA 1115052) and an INTA-INIA (Spain) cooperation agreement. Work at UPF and CBMSO was supported by MINECO, Spain (Grant no. AGL2014-52395-C2) © 2018 I. Soria et al. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Foot-and-mouth disease Dendrimers Peptides Immune response and partial protection against heterologous foot-and-mouth disease virus induced by dendrimer peptides in cattle info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion