2026-04-17T07:18:58Zhttps://recercat.cat/oai/request
oai:recercat.cat:10230/356312025-12-24T09:01:58Zcom_2072_6col_2072_452952
RECERCAT author Hernández-Ruiz, Eugenia author Toll Abelló, Agustín author García-Díez, Irene author Andrades, Evelyn author Ferrandiz-Pulido, Carla author Masferrer, Emili author Yébenes, Mireia author Jaka, Ane author Gimeno Beltran, Javier author Gimeno Martínez, Ramón author García-Patos, Vicenç author Pujol Vallverdú, Ramon Maria author Hernández-Muñoz, Inmaculada 2018-10-23T07:39:52Z2018 Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy in humans and approximately 5% metastasize, usually to regional lymph nodes. Epigenetic regulation of gene expression may allow tumoral cells to acquire new functions in order to escape from the primary tumor. The aim of this study was to investigate the expression and function of proteins of the Polycomb family of epigenetic regulators in the metastatic process of cSCC. A higher expression of RING1B and EZH2 was detected by immunohistochemistry in a series of primary cSCC tumors that metastasized (MSCCs) when compared with non-metastasizing cSCCs (non-MSCCs). Stable downregulation of RING1B and EZH2 in cSCC cells results in enhanced expression of inflammatory cytokines and activation of the NF-κB signaling pathway. Accordingly, non-MSCCs display higher levels of membranous pS176-inhibitor of NF-kB kinase, and their stroma is enriched in neutrophils and eosinophils when compared with MSCCs. In vitro, hematopoietic cells exhibit a substantial migratory response to supernatants from Polycomb-depleted cSCC cells. Altogether, these data indicate that RING1B and EZH2 repress the innate inflammatory cSCC function and impair tumor immunosurveillance and suggest that patients with high-risk cSCCs could benefit from clinical therapies addressed to harness the immune response. © Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in Carcinogenesis following peer review. The version of record Hernández-Ruiz E, Toll A, García-Diez I, Andrades E, Ferrandiz-Pulido C, Masferrer E. et al. The Polycomb proteins RING1B and EZH2 repress the tumoral pro-inflammatory function in metastasizing primary cutaneous squamous cell carcinoma. Carcinogenesis. 2018 Mar 8;39(3):503-513 is available online at: http://dx.doi.org/10.1093/carcin/bgy016 info:eu-repo/semantics/openAccess Pell -- Càncer The Polycomb proteins RING1B and EZH2 repress the tumoral pro-inflammatory function in metastasizing primary cutaneous squamous cell carcinoma info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion