2026-04-14T06:40:06Zhttps://recercat.cat/oai/request
oai:recercat.cat:10230/356302025-12-20T17:09:00Zcom_2072_6col_2072_452952
RECERCAT author Batalla, Albert author Lorenzetti, Valentina author Chye ,Yann author Yucel, Murat author Soriano Mas, Carles author Bhattacharyya, Sagnik author Torrens, Marta author Crippa, José A.S. author Martín Santos, Rocío 2018-10-23T07:39:46Z2018-10-23T07:39:46Z2018 Introduction: Hippocampal neuroanatomy is affected by genetic variations in dopaminergic candidate genes and environmental insults, such as early onset of chronic cannabis exposure. Here, we examine how hippocampal total and subregional volumes are affected by cannabis use and functional polymorphisms of dopamine-relevant genes, including the catechol-O-methyltransferase (COMT), dopamine transporter (DAT1), and the brain-derived neurotrophic factor (BDNF) genes. Material and Methods: We manually traced total hippocampal volumes and automatically segmented hippocampal subregions using high-resolution MRI images, and performed COMT, DAT1, and BDNF genotyping in 59 male Caucasian young adults aged 18-30 years. These included 30 chronic cannabis users with early-onset (regular use at <16 years) and 29 age-, education-, and intelligence-matched controls. Results: Cannabis use and dopaminergic gene polymorphism had both distinct and interactive effects on the hippocampus. We found emerging alterations of hippocampal total and specific subregional volumes in cannabis users relative to controls (i.e., CA1, CA2/3, and CA4), and associations between cannabis use levels and total and specific subregional volumes. Furthermore, total hippocampal volume and the fissure subregion were affected by cannabis×DAT1 polymorphism (i.e., 9/9R and in 10/10R alleles), reflecting high and low levels of dopamine availability. Conclusion: These findings suggest that cannabis exposure alters the normal relationship between DAT1 polymorphism and the anatomy of total and subregional hippocampal volumes, and that specific hippocampal subregions may be particularly affected. Copyright © Albert Batalla et al. 2018; Published by Mary Ann Liebert, Inc. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Hipocamp (Cervell) Cannabis -- Efectes secundaris Brain-derived neurotrophic factor Cannabis Catechol-O-methyltransferase gene Dopamine transporter gene Hippocampal subfields Hippocampus The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion