2026-04-14T02:13:51Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/262302025-12-18T01:22:26Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Davey, Christopher G. author Pujol, Jesús author Harrison, Ben J. author 2016-05-02T11:02:29Z 2016 The brain's default mode network (DMN) has become closely associated with self-referential mental activity, particularly in the resting-state. While the DMN is important for such processes, it has functions other than self-reference, and self-referential processes are supported by regions outside of the DMN. In our study of 88 participants, we examined self-referential and resting-state processes to clarify the extent to which DMN activity was common and distinct between the conditions. Within areas commonly activated by self-reference and rest we sought to identify those that showed additional functional specialization for self-referential processes: these being not only activated by self-reference and rest but also showing increased activity in self-reference versus rest. We examined the neural network properties of the identified 'core-self' DMN regions-in medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and inferior parietal lobule-using dynamic causal modeling. The optimal model identified was one in which self-related processes were driven via PCC activity and moderated by the regulatory influences of MPFC. We thus confirm the significance of these regions for self-related processes and extend our understanding of their functionally specialized roles. This study was funded by a National Health and Medical Research Council of Australia (NHMRC) Project Grant (1064643; Principal Investigator, BJH). CGD was supported by an NHMRC Career Development Fellowship (1061757). Cervell -- Fisiologia Cervell -- Localització de funcions Mapping the self in the brain's default mode network