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From chromatin to splicing: RNA-processing as a total artwork Tilgner, Hagen, 1980- Guigó Serra, Roderic Cromatina RNA missatger Exons Splicing Transcription Chromatin Epigenetics Nucleosome positioning Bioinformatics RNA plays a central role in the determination of the phenotype of the cell. The molecular mechanisms involved in primary RNA synthesis and subsequent post-processing are not completely understood, but there is increasing evidence that they are more tightly coupled than previously expected. The analyses by a number of groups of recently published genome wide maps of chromatin structure have further uncovered a role for primary chromatin structure in RNA processing. Indeed, these analyses have revealed that nucleosomes show a characteristic occupancy pattern in exonic regions of metazoan genomes. The pattern is strongly indicative of an implication of nucleosome positioning in exon recognition during pre-mRNA splicing. Characteristic exonic patterns have also been observed for a number of histone modifications, suggesting the possibility that chromatin state plays a direct role in the regulation of splicing 2016-01-12T13:32:06Z 2016-01-12T13:32:06Z 2010 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Tilgner H, Guigó R. From chromatin to splicing: RNA-processing as a total artwork. Epigenetics. 2010; 5(3): 180-184. DOI 10.4161/epi.5.3.11319 1559-2294 http://hdl.handle.net/10230/25556 http://dx.doi.org/10.4161/epi.5.3.11319 eng Epigenetics. 2010; 5(3): 180-184 © 2010 Landes Bioscience. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. https://creativecommons.org/licenses/by-nc/3.0/ info:eu-repo/semantics/openAccess application/pdf application/pdf Taylor & Francis (Routledge)