2026-04-14T06:49:23Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/255562025-12-12T01:34:55Zcom_2072_6col_2072_452952

urn:hdl:10230/25556 From chromatin to splicing: RNA-processing as a total artwork Tilgner, Hagen, 1980- Guigó Serra, Roderic Cromatina RNA missatger Exons Splicing Transcription Chromatin Epigenetics Nucleosome positioning Bioinformatics RNA plays a central role in the determination of the phenotype of the cell. The molecular mechanisms involved in primary RNA synthesis and subsequent post-processing are not completely understood, but there is increasing evidence that they are more tightly coupled than previously expected. The analyses by a number of groups of recently published genome wide maps of chromatin structure have further uncovered a role for primary chromatin structure in RNA processing. Indeed, these analyses have revealed that nucleosomes show a characteristic occupancy pattern in exonic regions of metazoan genomes. The pattern is strongly indicative of an implication of nucleosome positioning in exon recognition during pre-mRNA splicing. Characteristic exonic patterns have also been observed for a number of histone modifications, suggesting the possibility that chromatin state plays a direct role in the regulation of splicing 2016-01-12T13:32:06Z 2016-01-12T13:32:06Z 2010 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Epigenetics. 2010; 5(3): 180-184 © 2010 Landes Bioscience. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. https://creativecommons.org/licenses/by-nc/3.0/ info:eu-repo/semantics/openAccess Taylor & Francis (Routledge)