2026-04-14T03:17:30Zhttps://recercat.cat/oai/requestoai:recercat.cat:10230/252182025-12-21T17:57:30Zcom_2072_6col_2072_452952
RECERCAT
author
Azzaoui, Kamal
author
Jacoby, Edgar
author
Senger, Stefan
author
Cuadrado Rodríguez, Emiliano
author
Loza, Mabel
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Zdrazil, Barbara
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Pinto, Marta
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Williams, Antony J.
author
Torre, Victor de la
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Mestres i López, Jordi
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Pastor Maeso, Manuel
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Taboureau, Olivier
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Rarey, Matthias
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Chichester, Christine
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Pettifer, Steve
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Blomberg, Niklas
author
Harland, Lee
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Williams-Jones, Bryn
author
Ecker, Gerhard F.
2015-11-25T15:43:47Z2015-11-25T15:43:47Z2013
Molecular information systems play an important part in modern data-driven drug discovery. They do not only support decision making but also enable new discoveries via association and inference. In this review, we outline the scientific requirements identified by the Innovative Medicines Initiative (IMI) Open PHACTS consortium for the design of an open pharmacological space (OPS) information system. The focus of this work is the integration of compound-target-pathway-disease/phenotype data for public and industrial drug discovery research. Typical scientific competency questions provided by the consortium members will be analyzed based on the underlying data concepts and associations needed to answer the questions. Publicly available data sources used to target these questions as well as the need for and potential of semantic web-based technology will be presented.The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. [115191], resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013) and inkind contribution of EFPIA companies.
© 2013 Elsevier Ltd. All rights reserved. info:eu-repo/semantics/openAccess
Medicaments -- Desenvolupament
Farmàcia -- Investigació
Mineria de dades
Scientific competency questions as the basis for semantically enriched open pharmacological space development
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion