2026-04-17T19:02:56Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/252182025-12-21T17:57:30Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Azzaoui, Kamal author Jacoby, Edgar author Senger, Stefan author Cuadrado Rodríguez, Emiliano author Loza, Mabel author Zdrazil, Barbara author Pinto, Marta author Williams, Antony J. author Torre, Victor de la author Mestres i López, Jordi author Pastor Maeso, Manuel author Taboureau, Olivier author Rarey, Matthias author Chichester, Christine author Pettifer, Steve author Blomberg, Niklas author Harland, Lee author Williams-Jones, Bryn author Ecker, Gerhard F. author 2015-11-25T15:43:47Z 2015-11-25T15:43:47Z 2013 Molecular information systems play an important part in modern data-driven drug discovery. They do not only support decision making but also enable new discoveries via association and inference. In this review, we outline the scientific requirements identified by the Innovative Medicines Initiative (IMI) Open PHACTS consortium for the design of an open pharmacological space (OPS) information system. The focus of this work is the integration of compound-target-pathway-disease/phenotype data for public and industrial drug discovery research. Typical scientific competency questions provided by the consortium members will be analyzed based on the underlying data concepts and associations needed to answer the questions. Publicly available data sources used to target these questions as well as the need for and potential of semantic web-based technology will be presented. The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. [115191], resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013) and inkind contribution of EFPIA companies. Medicaments -- Desenvolupament Farmàcia -- Investigació Mineria de dades Scientific competency questions as the basis for semantically enriched open pharmacological space development