2026-04-17T11:43:56Zhttps://recercat.cat/oai/requestoai:recercat.cat:10230/248462025-12-26T11:18:19Zcom_2072_6col_2072_452952
RECERCAT
author
Baulida i Estadella, Josep, 1965-
author
García de Herreros, Antonio
2015-10-14T11:20:30Z2016-08-31T02:00:04Z2015
The transcription factor Snail1 induces epithelial-to-mesenchymal transition (EMT) in tumor epithelial cells, a process associated with the emergence of stemness, invasion and cancer malignancy. Here, we review recent reports indicating that Snail1 also regulates mesenchymal plasticity and paracrine signaling and propose that Snail1 orchestrates the generation of cancer stem cells (CSCs) and cancer-associated fibroblasts (CAFs). Our view supports the current models for tumorigenesis that consider stemness and tumor microenvironment as retroactive actors for metastasis formation, revealing Snail1 as a regulator of these metastatic forces. This view offers new perspectives for understanding and targeting metastasis.
© 2015 Elsevier B.V. All rights reserved info:eu-repo/semantics/openAccess
Metastasis
EMT Epithelial to mesenchymal transition
Snail1
CAF Cancer associated fibroblasts
CSC Cancer stem cell
Tumor microenvironment
Mechanical signalling
TGF-beta
Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy.
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion