2026-04-14T04:36:42Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/248462025-12-26T11:18:19Zcom_2072_6col_2072_452952

00925njm 22002777a 4500 dc Baulida i Estadella, Josep, 1965- author García de Herreros, Antonio author 2015-10-14T11:20:30Z 2016-08-31T02:00:04Z 2015 The transcription factor Snail1 induces epithelial-to-mesenchymal transition (EMT) in tumor epithelial cells, a process associated with the emergence of stemness, invasion and cancer malignancy. Here, we review recent reports indicating that Snail1 also regulates mesenchymal plasticity and paracrine signaling and propose that Snail1 orchestrates the generation of cancer stem cells (CSCs) and cancer-associated fibroblasts (CAFs). Our view supports the current models for tumorigenesis that consider stemness and tumor microenvironment as retroactive actors for metastasis formation, revealing Snail1 as a regulator of these metastatic forces. This view offers new perspectives for understanding and targeting metastasis. Metastasis EMT Epithelial to mesenchymal transition Snail1 CAF Cancer associated fibroblasts CSC Cancer stem cell Tumor microenvironment Mechanical signalling TGF-beta Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy.