2026-04-13T00:53:57Zhttps://recercat.cat/oai/request
oai:recercat.cat:10230/236122025-12-13T21:28:19Zcom_2072_6col_2072_452952
RECERCAT author Riera Oliva, Marta author Márquez, Eva author Clotet, Sergi author Gimeno Beltran, Javier author Roca-Ho, Heleia author Lloreta, Josep, 1958- author Juanpere, Nuria author Batlle, Daniel author Pascual Santos, Julio author Soler, María José 2015-05-22T07:45:18Z2015-05-22T07:45:18Z2014 We studied the non-obese diabetic (NOD) mice model because it develops autoimmune diabetes that resembles human type 1 diabetes. In diabetic mice, urinary albumin excretion (UAE) was ten-fold increased at an “early stage” of diabetes, and twenty-fold increased at a “later stage” (21 and 40 days, respectively after diabetes diagnosis) as compared to non-obese resistant controls. In NOD Diabetic mice, glomerular enlargement, increased glomerular filtration rate (GFR) and increased blood pressure were observed in the early stage. In the late stage, NOD Diabetic mice developed mesangial expansion and reduced podocyte number. Circulating and urine ACE2 activity were markedly increased both, early and late in Diabetic mice. Insulin administration prevented albuminuria, markedly reduced GFR, blood pressure, and glomerular enlargement in the early stage; and prevented mesangial expansion and the reduced podocyte number in the late stage of diabetes. The increase in serum and urine ACE2 activity was normalized by insulin administration at the early and late stages of diabetes in Diabetic mice. We conclude that the Diabetic mice develops features of early kidney disease, including albuminuria and a marked increase in GFR. ACE2 activity is increased starting at an early stage in both serum and urine. Moreover, these alterations can be completely prevented by the chronic administration of insulin.This work was supported by grants from the Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation (ISCIII-FEDER. PI081688), and Fundación Senefro. J.P. is funded in part through the project ISCIII-FEDER PI10/01370 © 2014 Riera et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited info:eu-repo/semantics/openAccess Diabetis Insulina Ronyons -- Malalties Pèptids Effect of insulin on ACE2 activity and kidney function in the non-obese diabetic mouse info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion