2026-04-17T17:00:19Zhttps://recercat.cat/oai/request
oai:recercat.cat:10230/233612025-12-13T21:28:55Zcom_2072_6col_2072_452952
RECERCAT author Martel-Pelletier, Johanne author Farran Díaz Cano, Aina author Montell, Eulàlia author Vergés, Josep author Pelletier, Jean-Pierre 2015-04-08T10:48:09Z2015-04-08T10:48:09Z2015 Osteoarthritis is a common, progressive joint disease, and treatments generally aim for symptomatic improvement. However, SYmptomatic Slow-Acting Drugs in Osteoarthritis (SYSADOAs) not only reduce joint pain, but slow structural disease progression. One such agent is chondroitin sulfate-a complex, heterogeneous polysaccharide. It is extracted from various animal cartilages, thus has a wide range of molecular weights and different amounts and patterns of sulfation. Chondroitin sulfate has an excellent safety profile, and although various meta-analyses have concluded that it has a beneficial effect on symptoms and structure, others have concluded little or no benefit. This may be due, at least partly, to variations in the quality of the chondroitin sulfate used for a particular study. Chondroitin sulfate is available as pharmaceutical- and nutraceutical-grade products, and the latter have great variations in preparation, composition, purity and effects. Moreover, some products contain a negligible amount of chondroitin sulfate and among samples with reasonable amounts, in vitro testing showed widely varying effects. Of importance, although some showed anti-inflammatory effects, others demonstrated weak effects, and some instances were even pro-inflammatory. This could be related to contaminants, which depend on the origin, production and purification process. It is therefore vitally important that only pharmaceutical-grade chondroitin sulfate be used for treating osteoarthritis patients This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Reumatisme articular degeneratiu Discrepancies in Composition and Biological Effects of Different Formulations of Chondroitin Sulfate info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion