2026-04-18T07:49:19Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/231262025-12-18T01:20:49Zcom_2072_6col_2072_452952

Rich club organization supports a diverse set of functional network configurations Senden, Mario Deco, Gustavo Reus, Marcel A. de Goebel, Rainer Heuvel, Martijn van den Rich club Functional repertoire Connectivity Spin glass model Connectome Brain function relies on the flexible integration of a diverse set of segregated cortical/nmodules, with the structural connectivity of the brain being a fundamentally important factor/nin shaping the brain‟s functional dynamics. Following up on macroscopic studies showing the/nexistence of centrally connected nodes in the mammalian brain, combined with the notion that/nthese putative brain hubs may form a dense interconnected „rich club‟ collective, we/nhypothesized that brain connectivity might involve a rich club type of architecture to promote/na repertoire of different and flexibly accessible brain functions. With the rich club suggested/nto play an important role in global brain communication, examining the effects of a rich club/norganization on the functional repertoire of physical systems in general, and the brain in/nparticular, is of keen interest. Here we elucidate these effects using a spin glass model of/nneural networks for simulating stable configurations of cortical activity. Using simulations,/nwe show that the presence of a rich club increases the set of attractors and hence the diversity/nof the functional repertoire over and above the effects produced by scale free type topology/nalone. Within the networks‟ overall functional repertoire rich nodes are shown to be important/nfor enabling a high level of dynamic integrations of low-degree nodes to form functional/nnetworks. This suggests that the rich club serves as an important backbone for numerous co-/nactivation patterns among peripheral nodes of the network. In addition, applying the spin/nglass model to empirical anatomical data of the human brain, we show that the positive effects/non the functional repertoire attributed to the rich club phenomenon can be observed for the/nbrain as well. We conclude that a rich club organization in network architectures may be/ncrucial for the facilitation and integration of a diverse number of segregated functions. Authors MS and RG were supported by the European Research Council under the European Union's Seventh Framework Programme (ERC-2010-AdG, ERC grant agreement no. 269853). Author GD was supported by the ERC Advanced Grant: DYSTRUCTURE (n. 295129), by the Spanish Research ProjectSAF2010-16085 and by European Community's Seventh Framework Programme under the project “BrainScales” (project number 269921). Author MPvdH was supported by a VENI grant of The Netherlands Organization for Scientific Research (NWO) (451-12-001) and by a Fellowship of the Brain Center Rudolf Magnus. 2015-02-12T08:19:25Z 2015-02-12T08:19:25Z 2014 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Senden M, Deco G, de Reus MA, Goebel R, van den Heuvel MP. Rich club organization supports a diverse set of functional network configurations. NeuroImage. 2014 Aug;96:174–82. DOI 10.1016/j.neuroimage.2014.03.066 1053-8119 http://hdl.handle.net/10230/23126 http://dx.doi.org/10.1016/j.neuroimage.2014.03.066 eng NeuroImage. 2014 Aug;96:174–82 info:eu-repo/grantAgreement/EC/FP7/295129 info:eu-repo/grantAgreement/EC/FP7/269853 info:eu-repo/grantAgreement/EC/FP7/269921 info:eu-repo/grantAgreement/ES/3PN/SAF2010-16085 © Elsevier http://dx.doi.org/10.1016/j.neuroimage.2014.03.066 info:eu-repo/semantics/openAccess application/pdf application/pdf Elsevier