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oai:recercat.cat:10230/230772025-12-24T09:03:26Zcom_2072_6col_2072_452952

Ongoing cortical activity at rest: criticality, multistability,/nand ghost attractors Deco, Gustavo Jirsa, Viktor K. The ongoing activity of the brain at rest, i.e., under no stimulation and in absence of any task, is astonishingly highly structured into/nspatiotemporal patterns. These spatiotemporal patterns, called resting state networks, display low-frequency characteristics (<0.1 Hz)/nobserved typically in the BOLD-fMRI signal of human subjects. We aim here to understand the origins of resting state activity through/nmodeling via a global spiking attractor network of the brain. This approach offers a realistic mechanistic model at the level of each single/nbrain area based on spiking neurons and realistic AMPA, NMDA, and GABA synapses. Integrating the biologically realistic diffusion/ntensor imaging/diffusion spectrum imaging-based neuroanatomical connectivity into the brain model, the resultant emerging resting/nstate functional connectivity of the brain network fits quantitatively best the experimentally observed functional connectivity in humans/nwhen the brain network operates at the edge of instability. Under these conditions, the slow fluctuating (</n0.1 Hz) resting state networks/nemerge as structured noise fluctuations around a stable low firing activity equilibrium state in the presence of latent “ghost” multistable/nattractors. The multistable attractor landscape defines a functionally meaningful dynamic repertoire of the brain network that is inher-/nently present in the neuroanatomical connectivity. G.D. was supported by the European Union Grant EC005-024, by SAF2010-16085 and the “La Marato”/nFoundation,andbytheCONSOLIDER-INGENIO2010ProgrammeCSD2007-00012.The research reported here in was/nsupported by the Brain Network Recovery Group through the James S. McDonnell Foundation and the FP7-ICT/nBrainScales. 2015-01-27T08:32:03Z 2015-01-27T08:32:03Z 2012 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Deco G, Jirsa VK. Ongoing cortical activity at rest: criticality, multistability, and ghost attractors. J Neurosci. 2012 Mar;32(10):3366-75. DOI 10.1523/JNEUROSCI.2523-11.2012 0270-6474 http://hdl.handle.net/10230/23077 http://dx.doi.org/10.1523/JNEUROSCI.2523-11.2012 eng The Journal of Neuroscience. 2012 Mar;32(10):3366-75 info:eu-repo/grantAgreement/EC/FP7/295129 info:eu-repo/grantAgreement/EC/FP7/269921 info:eu-repo/grantAgreement/ES/3PN/SAF2010-16085 info:eu-repo/grantAgreement/ES/2PN/CSD2007-00012 The work is published under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ http://creativecommons.org/licenses/by-nc-sa/3.0/ info:eu-repo/semantics/openAccess 10 p. application/pdf application/pdf Society for Neuroscience