2026-04-13T00:51:58Zhttps://recercat.cat/oai/requestoai:recercat.cat:10230/230772025-12-24T09:03:26Zcom_2072_6col_2072_452952
RECERCAT
author
Deco, Gustavo
author
Jirsa, Viktor K.
2015-01-27T08:32:03Z2015-01-27T08:32:03Z2012
The ongoing activity of the brain at rest, i.e., under no stimulation and in absence of any task, is astonishingly highly structured into/nspatiotemporal patterns. These spatiotemporal patterns, called resting state networks, display low-frequency characteristics (<0.1 Hz)/nobserved typically in the BOLD-fMRI signal of human subjects. We aim here to understand the origins of resting state activity through/nmodeling via a global spiking attractor network of the brain. This approach offers a realistic mechanistic model at the level of each single/nbrain area based on spiking neurons and realistic AMPA, NMDA, and GABA synapses. Integrating the biologically realistic diffusion/ntensor imaging/diffusion spectrum imaging-based neuroanatomical connectivity into the brain model, the resultant emerging resting/nstate functional connectivity of the brain network fits quantitatively best the experimentally observed functional connectivity in humans/nwhen the brain network operates at the edge of instability. Under these conditions, the slow fluctuating (</n0.1 Hz) resting state networks/nemerge as structured noise fluctuations around a stable low firing activity equilibrium state in the presence of latent “ghost” multistable/nattractors. The multistable attractor landscape defines a functionally meaningful dynamic repertoire of the brain network that is inher-/nently present in the neuroanatomical connectivity.G.D. was supported by the European Union Grant EC005-024, by SAF2010-16085 and the “La Marato”/nFoundation,andbytheCONSOLIDER-INGENIO2010ProgrammeCSD2007-00012.The research reported here in was/nsupported by the Brain Network Recovery Group through the James S. McDonnell Foundation and the FP7-ICT/nBrainScales.
The work is published under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ http://creativecommons.org/licenses/by-nc-sa/3.0/ info:eu-repo/semantics/openAccess
Ongoing cortical activity at rest: criticality, multistability,/nand ghost attractors
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion