2026-04-14T09:11:55Zhttps://recercat.cat/oai/request

oai:recercat.cat:10230/124252025-12-24T08:52:47Zcom_2072_6col_2072_452952

Multi-receptor binding profile of clozapine and olanzapine: a structural study based on the new beta (2) adrenergic receptor template López Muñoz, Laura Pastor Maeso, Manuel Sanz, Ferran Selent, Jana Serotonina Esquizofrènia -- Quimioteràpia Esquizofrènia Schizophrenia is a devastating mental disorder that has a large/nimpact on the quality of life for those who are afflicted and is/nvery costly for families and society.[1] Although the etiology of/nschizophrenia is still unknown and no cure has yet been/nfound, it is treatable, and pharmacological therapy often produces/nsatisfactory results. Among the various antipsychotic/ndrugs in use, clozapine is widely recognized as one ofthe/nmost clinically effective agents, even if it elicits significant side/neffects such as metabolic disorders and agranulocytosis. Clozapine/nand the closely related compound olanzapine are good/nexamples ofdrug s with a complex multi-receptor profile ;[2]/nthey have affinities toward serotonin, dopamine, a adrenergic,/nmuscarinic, and histamine receptors, among others. 2011-07-27T08:27:56Z 2011-07-27T08:27:56Z 2008 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Selent J, López L, Sanz F, Pastor M. Multi-Receptor Binding Profile of Clozapine and Olanzapine: A Structural Study Based on the New β2 Adrenergic Receptor Template. ChemMedChem. 2008;3(8):1194-8. DOI: 10.1002/cmdc.200800074 1860-7179 http://hdl.handle.net/10230/12425 http://dx.doi.org/10.1002/cmdc.200800074 eng ChemMedChem. 2008;3(8):1194-8 © 2008 Wiley-VCH Verlag GmbH& Co. KGaA, Weinheim info:eu-repo/semantics/openAccess application/pdf application/pdf Wiley-Blackwell