This final career thesis (Master thesis) is a contribution on the enhancement of wireless communications, specifically WLAN multi-cell systems based on the IEEE 802.11 standard. The objectives were to propose and study different Cross-Layer AP selection mechanisms that include single, dual and multiple metric based criteria using PHY-MAC interactions. These mechanisms are designed in order to improve system efficiency through the increase of the utilization of the available transmission resources. The key idea of these mechanisms is to make use of certain PHY and MAC parameters, other than the traditional RSSI measurements, in order to optimize the association to the best AP, specially focusing on the innovative use of MAC level state metrics. In this regard, of special interest is the inclusion of MAC level AP traffic load estimations within these association decisions. All the proposals are based on the use of a high-performance MAC protocol called DQCA (Distributed Queueing Collision Avoidance), which is specially fitted to include the proposed techniques. Computer simulations have been carried out to evaluate and quantify the benefits of the proposed mechanisms and techniques in representative scenarios. Moreover, a completely new handoff procedure has been designed for the DQCA muti-cell operation. This handoff process allows implementing each of the proposed AP selection mechanisms. Furthermore, the interaction between a Cross-Layer scheduling technique at the MAC level and two proposed AP selection mechanisms has also been studied. The performance of these techniques has also been assessed by means of computer simulations. The analysis of the obtained results show that the proposed mechanisms perform differently under the considered scenarios. However, the main conclusion that can be drawn is that AP selection mechanisms that are based on joint multiple metrics considerations (SNR, AP load, delay, etc.) perform significantly better than those that use only single or dual metric based mechanisms. After the study, we can conclude that the proposed techniques and mechanisms provide significant efficiency enhancements for DQCA-based WLAN multi-cell systems so that all of them may be taken into account in future wireless networks.