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Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model.
Costelli, Paola; Carbó Carbó, Neus; Tessitore, Luciana; Bagby, Gregory J.; López-Soriano, Francisco J.; Argilés Huguet, Josep Ma.; Baccino, Francesco M.
Universitat de Barcelona
Rats bearing the Yoshida AH-130 ascites hepatoma showed enhanced fractional rates of protein degradation in gastrocnemius muscle, heart, and liver, while fractional synthesis rates were similar to those in non-tumor bearing rats. This hypercatabolic pattern was associated with marked perturbations of the hormonal homeostasis and presence of tumor necrosis factor in the circulation. The daily administration of a goat anti-murine TNF IgG to tumor-bearing rats decreased protein degradation rates in skeletal muscle, heart, and liver as compared with tumor-bearing rats receiving a nonimmune goat IgG. The anti-TNF treatment was also effective in attenuating early perturbations in insulin and corticosterone homeostasis. Although these results suggest that tumor necrosis factor plays a significant role in mediating the changes in protein turnover and hormone levels elicited by tumor growth, the inability of such treatment to prevent a reduction in body weight implies that other mediators or tumor-related events were also involved.
Tumors
Necrosi
Músculs
Tumor necrosis factor
Skeletal muscle
Protein turnover
(c) The American Society for Clinical Investigation, 1993
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info:eu-repo/semantics/publishedVersion
American Society for Clinical Investigation
         

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