Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/8311

Effects of erythropoietin on muscle O2 transport during exercise in patients with chronic renal failure.
Marrades Sicart, Ramon Ma.; Roca Torrent, Josep; Campistol Plana, Josep M.; Díaz, Orlando; Barberà i Mir, Joan Albert; Torregrosa Prats, José Vicente; Masclans, Joan R.; Cobos Carbó, Alberto; Rodríguez-Roisin, Robert; Wagner, P. D. (Peter D.)
Universitat de Barcelona
Erythropoietin (rHuEPO) has proven to be effective in the treatment of anemia of chronic renal failure (CRF). Despite improving the quality of life, peak oxygen uptake after rHuEPO therapy is not improved as much as the increase in hemoglobin concentration ([Hb)] would predict. We hypothesized that this discrepancy is due to failure of O2 transport rates to rise in a manner proportional to [Hb]. To test this, eight patients with CRF undergoing regular hemodialysis were studied pre- and post-rHuEPO ([Hb] = 7.5 +/- 1.0 vs. 12.5 +/- 1.0 g x dl-1) using a standard incremental cycle exercise protocol. A group of 12 healthy sedentary subjects of similar age and anthropometric characteristics served as controls. Arterial and femoral venous blood gas data were obtained and coupled with simultaneous measurements of femoral venous blood flow (Qleg) by thermodilution to obtain O2 delivery and oxygen uptake (VO2). Despite a 68% increase in [Hb], peak VO2 increased by only 33%. This could be explained largely by reduced peak leg blood flow, limiting the gain in O2 delivery to 37%. At peak VO2, after rHuEPO, O2 supply limitation of maximal VO2 was found to occur, permitting the calculation of a value for muscle O2 conductance from capillary to mitochondria (DO2). While DO2 was slightly improved after rHuEPO, it was only 67% of that of sedentary control subjects. This kept maximal oxygen extraction at only 70%. Two important conclusions can be reached from this study. First, the increase in [Hb] produced by rHuEPO is accompanied by a significant reduction in peak blood flow to exercising muscle, which limits the gain in oxygen transport. Second, even after restoration of [Hb], O2 conductance from the muscle capillary to the mitochondria remains considerably below normal.
Exercici
Eritropoetina
Insuficiència renal crònica
Exercise
Leg blood flow
Muscle O2 conductance
Oxygen delivery
Oxygen uptake
(c) The American Society for Clinical Investigation, 1996
Artículo
American Society for Clinical Investigation
         

Mostrar el registro completo del ítem

Documentos relacionados

Otros documentos del mismo autor/a

Marrades Sicart, Ramon Ma.; Alonso, Juli; Roca Torrent, Josep; González de Suso, José M.; Campistol Plana, Josep M.; Barberà i Mir, Joan Albert; Díaz, Orlando; Torregrosa Prats, José Vicente; Masclans, Joan R.; Rodríguez-Roisin, Robert; Wagner, P. D. (Peter D.)
Rodríguez-Roisin, Robert; Félez Flor, Miguel Ángel; Chung, K. Fan; Barberà i Mir, Joan Albert; Wagner, P. D. (Peter D.); Cobos Carbó, Alberto; Barnes, Peter J.; Roca Torrent, Josep
Rodríguez-Roisin, Robert; Félez Flor, Miguel Ángel; Chung, K. Fan; Barberà i Mir, Joan Albert; Wagner, P. D. (Peter D.); Cobos Carbó, Alberto; Barnes, Peter J.; Roca Torrent, Josep
Rodríguez-Roisin, Robert; Félez Flor, Miguel Ángel; Chung, K. Fan; Barberà i Mir, Joan Albert; Wagner, Peter D.; Cobos Carbó, Alberto; Barnes, Peter J.; Roca Torrent, Josep
Rodríguez-Roisin, Robert; Félez Flor, Miguel Ángel; Chung, K. Fan; Barberà i Mir, Joan Albert; Wagner, Peter D.; Cobos Carbó, Alberto; Barnes, Peter J.; Roca Torrent, Josep