Radical Cyclization of Trichloroacetamides: Synthesis of Lactams

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Title:	Radical Cyclization of Trichloroacetamides: Synthesis of Lactams
Author:	Coussanes, Guilhem; Vila, X.; Diaba, Faïza; Bonjoch i Sesé, Josep
Other authors:	Universitat de Barcelona
Abstract:	Trichloroacetamides can act as radical precursors to synthesize nitrogen-containing heterocycles in a variety of processes, mainly involving atom transfer radical cyclizations (ATRC), mediated by Cu(I) or Ru(II) catalysts, and the hydride reductive method, employing either Bu3SnH or (Me3Si)3SiH, or recently NaBH3CN. Additionally, amine-mediated single-electron transfer cyclizations, as well as radical processes promoted by Ni, Fe, Mn, Ti, and Ag, have been developed.
Subject(s):	-Lactames -Hidrurs -Lactams -Hydrides
Rights:	cc-by-nc-nd (c) Coussanes, G. et al., 2017 http://creativecommons.org/licenses/by-nc-nd/3.0/es
Document type:	Article Article - Published version
Published by:	Georg Thieme Verlag Stuttgart · New York
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